Research projects
| Project title | Topic | Short description | Project coordinator(s) | Projects status | Main supervisor | Contact Information |
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| Delayed cerebral ischemia in subarachnoid hemorrhage - Towards a novel pharmacological intervention | Neuroinflammatory involvement in subarachnoid hemorrhage and the development of DCI | We aim to investigate the temporal aspect of neuroinflammation and mitochondrial dysfunction brains tissue and vasculature in subarachnoid hemorrhage using an animal model. Furthermore we seek to investigate pharmacological intervention and its impact on the development of delayed cerebral ischemia, behavior and overall survival | Jesper Peter Bömers, MD | Ongoing. Expected end date 01.04.23 | Tiit Mathiesen | jesper.peter.boemers@regionh.dk . +45 61664720 |
| Surgeons experience of Venous risk with CP-angle Surgery | Safe handling of veins, Venous anatomy | A mixed method study Describing Surgical experience in the Cerebellopontine angle surgery with respect to safe handling of veins. | Medical student, Adam A. Ismaili | Tiit Mathiesen | bdk899@alumni.ku.dk 26156635 |
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| Malignant meningioma: Clinical, temporal and spatial heterogeneity | Meningiomas, oncology, tumor biology, neuropathlogy | A series of retrospective studies investigating the molecular biology of meningioma in relation to diagnosis, prognosis and treatment | Ph.D. student, Andrea Maier | Tiit Mathiesen | andrea.maier@regionh.dk +45 25825824 |
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| The Glymphatic System in Humans | Sleep and Intracranial pressure | Our aim is to investigate basic mechanisms of sleep and the hypothesis of a functioning glymphatic system in humans. | Ph.D. student Casper Schwartz Riedel | Marianne Juhler | casper.schwartz.riedel@regionh.dk | |
| Coupling sleep monitoring and reverse microdialysis to explore waste clearance in the human brain | Cerebral waste clearance and sleep | Developing a new method for the quantification of waste clearance in the human brain - coupled to sleep monitoring. | Medical student, Joachim Birch Milan | Marianne Juhler | joachim.birch.milan@regionh.dk | |
| The associations between hormonal therapy, prolactin and cerebral meningiomas | Meningiomas, oncology, epilepsy, neuropathlogy | Epidemiological and pathological research regarding the occurrence and development of intra cerebral meningiomas | Ph.D. student Laura Giraldi | Tina Munch | lvfg@ssi.dk 27 122 221 |
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| Reference Values for Intracranial Pressure | Intracranial pressure, hydrocephalus | A clinical, multicenter study aiming to determine accurate reference values for intracranial pressure | Medical student, Nicolas H. Norager | Marianne Juhler | nicolas.norager@gmail.com 31 71 32 82 |
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| Biomarkers and fluid dynamics in Hydrocephalus | Regulation of fluid production and transport in all types of hydrocephalus | A tandem research project with Associate Professor Nanna MacAulay and her research group (Department of Neuroscience, University of Copenhagen) funded by the Novo Nordisk Foundation. The aim is to elucidate the molecular mechanisms of fluid production in choroid plexus and gain more knowledge on ICP in both animal models and patients. | Post doc, Nina Rostgaard (PhD, MSc Human Biology) | Marianne Juhler | nina.rostgaard@regionh.dk 60 15 26 85 |
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| Development, validation and implementation of a relative’s involvement effort | Nursing, relatives, traumatic brain injury | The project aims to examinen the effect of a nursing intervention to ensure individualized involvement of relatives in the patient pathways after severe brain injury and brain tumor. Design: Qualitative study, Complex intervention. | Rikke Guldager, Pernille Reck Miller, Pernille Vinding Hansen, Mette Kristensen, Nikie Hjelmar De Place, Ingrid Poulsen, Anne Norup | Research protocol is in preparation Funding is continuously being applied for. Approvals: In preparation Project start: 01.08.19 Expected end date: 31.07.21 | Rikke Guldager | rikke.guldager.01@regionh.dk |
| Molecular targeted optical imaging for fluorescence guideded surgery for malignant tumors | Fluorescence guided surgery | Development and translation of fluorescent tracers for delineation of GBM - from preclinical evaluation to first-in-human. | Ph.D. student Sorel Kurbegovic | Andreas Kjaer Clinical Supervisor Jane Skjøth-Rasmussen | sorel@sund.ku.dk 60 93 77 63 |
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| The socio-economic impact of spine surgery | Epidemiology, spine surgery, patient reported outcome | We aim to investigate the socio-economic impact of spine surgery, and also further evaluate patient reported health-related outcomes on the basis of objective register-based information of health- and socio-economic outcomes. | PhD student Stian Solumsmoen | Rachid Bech-Azeddine | stian.iversen.solumsmoen@regionh.dk | |
| Danish RAndomized trial of external ventricular drainage cessation IN aneurysmal subarachnoid haemorrhage (DRAIN) | Aneurismal subarachnoid haemorrhage, external ventricular drain treatment | A controlled, randomized, clinical trial comparing prompt closure and gradual weaning of external ventricular drain treatment in patients with hydrocephalus following aneurismal subarachnoid haemorrhage | Ph.D. student Tenna Capion | Tiit Mathiesen | tenna.baek.capion@regionh.dk 2277 2588 |
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| Reliability and Sensitivity test of a New Clinical Scale to Assess Nociception in patients with disorders of consciousness | Neuro-intensive care unit, neurosurgical unit, neurorehabilitering | To investigate the interrater reliability of the Danish version of the Brain Injury Nociception Assessment Measure (BINAM) and to investigate BINAM's ability to capture changes due to the intervention. Multicenter study. | Rikke Guldager, Pernille Reck Miller, Pernille Vinding Hansen, Ida Berthelsen, Simone Ahrenkilde, Ingrid Poulsen | Research protocol is in preparation Funding: In preparation Approvals: In preparation Project start: Autumn 2019 Expected end date: | Rikke Guldager | rikke.guldager.01@regionh.dk |